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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

Results were comparable to standard calorie restriction

Nevertheless, one doctor not affiliated with the research observed that there is not yet enough evidence to conclude that people with or at risk for acne should go out of their way to avoid eating foods rich in vitamin B (via Live Science)

Many sources emphasise that AOD 9604 is supportive not stand-alone miracle